P219 Migraine Is Associated with the Development of Inflammatory Bowel Disease: A Nationwide, Population-Based Study

Abstract Background Inflammatory bowel disease (IBD) has been associated with an increased risk of migraine in a nationwide cohort sample analysis, but there is no evidence on the impact development IBD The aim this study was to determine association between and IBD. Methods This population-based conducted using Korean National Health Insurance Service (NHIS) database. A total 10,628,070 people aged 20 years or older who had undergone national health examination by NHIS 2009 were followed up until 2017. population divided into two groups according presence absence migraine. We analyzed incidence newly developed IBD, Crohn’s (CD), ulcerative colitis (UC) during follow-up period. Results significantly higher patients (adjusted hazard ratio [aHR] 95% confidence interval [CI], 1.31 [1.173–1.468], p <0.001), CD (aHR CI, 1.58 [1.237–2.013], <0.001) UC 1.26 [1.106–1.424], than those without After 5 migraine, curves implying cumulative incidences showed steep increase especially for CD. In subgroup male sex (aHR, 1.431 vs. 1.117; interaction = 0.042) Conclusion Migraine Patients would be monitored carefully